NIH R01 · 2025
Project Abstract: Alzheimer’s disease (AD) and related dementias (ADRD) represent an enormous burden for patients, families, and health care systems, underscoring the urgent need for efficacious, widely-accessible, and cost- effective disease-modifying therapies. The over-production of longer, aggregation-prone Ab fragments (esp. Ab42 and 43) relative to shorter, non-aggregating fragments (esp. Ab37 and 38) appears to be a critical initiating pathological event in both late-onset, sporadic AD (LOAD) and Autosomal Dominant AD (ADAD). The balance between production of aggregating and non-aggregating forms of Ab is a direct result of the efficiency and kinetics with which the γ-secretase…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.