NIH R01 · 2024
A comprehensive study of APOE and the noncoding RNA AANCR to advance Alzheimer’s Disease treatment
PROJECT SUMMARY APOE4 is a major genetic risk factor for Alzheimer's Disease, which affects millions worldwide. In the United States, over 60% of Alzheimer's patients carry at least one APOE4 allele. Despite three decades of research, the absence of precision medicine targeting APOE4 remains a critical gap. Recent gene therapy breakthroughs, like mRNA vaccines and antisense oligonucleotide-based medicine, raise hope for APOE- focused Alzheimer's treatments. The APOE gene has three common alleles, E2, E3 and E4. APOE3 is the common allele, and it is not associated with susceptibility to Alzheimer’s Disease. APOE4 is the ancestral allele; although it is the susceptibility allele, its…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.