NIH R01 · 2024
Discovery of Addiction-Related Genes with Advanced Mouse Resources
PROJECT SUMMARY/ABSTRACT Our overarching goal is to discover the genetic and genomic mechanisms underlying behavioral predisposition and development of addiction. Addiction remains a substantial worldwide social and economic burden despite extensive efforts to curb drug availability and use. The high heritability of cocaine addiction, indicates that the propensity to develop a substance use disorder (SUD) after drug exposure is genetically influenced. Both human and animal studies indicate that behavioral traits such as novelty seeking are strongly correlated with the propensity to develop an SUD, but the biological basis of this relationship is unknown. We identify and characterize…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.