NIH R01 · 2024
preclinical optimization of BCMA directed T cell therapy
PROJECT SUMMARY The pillars of multiple myeloma (MM) therapy are DNA alkylators (cyclophosphamide, melphalan), proteasome inhibitors (bortezomib, carfilzomib, ixazomib), glucocorticoids (dexamethasone, prednisone) and IMiDs (thalidomide, lenalidomide, pomalidomide). Despite achieving an initial response, patients inevitably relapse and MM remains incurable. More recently, remarkable responses have been obtained with immunotherapy: antibodies against CD38 (daratumumab), bi-specific antibodies or BiTEs to BCMA, CAR-T cells against BCMA. However, similarly to what observed with conventional therapy, none of these immune-oncology agents are curative. We believe that in order to improve patient…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.