NIH R01 · 2024
Defining the role of microbiota-derived cyclic dinucleotides in priming antiviral immune defenses.
Enteric pathogens represent a major group of disease-causing agents, and must overcome the physical and immunological barrier of the gastrointestinal tract. The resident microbiota presents with a large array of ligands and pathogen-associated molecular patterns (PAMPs) which can prime immune defenses, through pattern recognition receptors (PRRs), both on enterocytes and immune resident cells. Indeed, microbial-derived TLR ligands are necessary for the development and maintenance of the intestinal barrier and immune homeostasis. Moreover, the microbiota is not static and imbalanced bacterial communities, termed dysbiosis, impact immunity, in particular during aging. Aging is associated with…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.