NIH R01 · 2024
Regulation of synapse development by small GTPase cascades in Caenorhabditis elegans
Project Summary Synaptic development is a highly conserved process that underlies the functional connectivity of the nervous system. Deficits in synaptic development are associated with multiple neurological disorders, like autism spectrum disorders, intellectual disabilities, epilepsy, and schizophrenia. Therefore, restoration of healthy synapse development in cases of neurodevelopmental disorders represents one goal for developing better treatments. However, the lack of molecular targets to achieve this goal presents a significant barrier to the development of new therapies. Identifying the signaling pathways that promote or restore synapse development will reveal new mechanisms for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.