NIH R01 · 2024
The Role of Cytoplasmic and Nuclear THEMIS in Immature and Mature T cells
Abstract THEMIS associates with a growing number of inflammatory diseases in humans, including Celiac Disease, Multiple Sclerosis and Atopic Dermatitis. THEMIS associated disorders affect different anatomical sites and follow different pathogeneses, placing THEMIS as one of the core “inflammatory”-controllers. Despite the strong association of THEMIS with multiple inflammatory diseases in humans and the profound defects in T cell development and selection in THEMIS-deficient mice, the function of THEMIS and the pathways or factors it interacts with remain enigmatic. THEMIS1 is expressed in T cells where it functions as a key adaptor downstream of the TCR. In thymocytes it is essential for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.