NIH R01 · 2025
Vagal and spinal afferent mapping of rat and human hearts in health and disease
The sensory system of the heart protects it from insult or injury but their overactivation and dysfunction are deleterious for cardiac function. However, the phenotypes of cardiac afferents, the regions they innervate, and the visceral reflexes they evoke are poorly documented. Associating specific afferent systems in terms of fiber type and neurochemical phenotype relative to the region they innervate and their sensory modality would inform future strategies to selectively modulate their activity for therapeutic gain in disease. To better understand the structural and functional roles of these afferent nerves, we will map both the vagal and spinal innervation of healthy and diabetic (Type…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.