NIH R01 · 2025
Treating knee osteoarthritis by sPLA2 inhibitor-loaded micellar nanoparticles
ABSTRACT Knee osteoarthritis (OA) is a painful and debilitating joint disease that can result in joint pain, loss of joint function, and deleterious effects on the quality of daily life. Despite recent advances in drug development, there is no disease-modifying drug available to delay OA progression or reverse the disease. Over 600,000 knee replacements are performed each year in the US. Many preclinical and clinical studies have revealed that various inflammatory mediators have been implicated in OA pathogenesis. Despite the strong association between inflammation and OA, a major challenge is how to resolve the inflammatory state since common anti-inflammatory drugs have demonstrated…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.