NIH R01 · 2024
Glycolipid biointerface to decipher disease-implicated ganglioside-protein interactions
Glycolipid biointerface to decipher disease-implicated ganglioside-protein interactions All cells in the human body, including neurons, immune cells, epithelial cells, and blood cells, are coated with a dense layer of glycoproteins and glycolipids known as the glycocalyx. The extraordinary complexity in structural organization and biosynthesis of the glycocalyx has made it very difficult to comprehend the precise roles it plays in various cellular processes and thus limited its potential as therapeutic target. An important family of molecules of the glycocalyx is gangliosides, which participate in a wide array of intercellular events such as modulating killer cell toxicity, controlling…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.