NIH R01 · 2025
Smad3-mediated gene-environment interaction and risk of tobacco-induced aneurysms
PROJECT SUMMARY Abdominal aortic aneurysm (AAA) is one of the most dreaded and fatal complications of tobacco use. Over 80% of people with a ruptured AAA will die, over 50% of them before reaching the hospital. Medical therapies for AAA are limited, and those with severe disease require surgical repair. There is an urgent need to develop better ways to prevent and slow the development of AAA. Clinical observations suggest two distinct avenues of potential intervention: one focused on understanding the genetic risks that lead to AAA, and the other focused on the epigenetic modifiers associated with AAA development. Our current understanding of the exact mechanism of either factor is impeded…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.