NIH R01 · 2025
Adventitial Fibroblast Phenotypic Modulation in Atherosclerosis
PROJECT SUMMARY New avenues of therapy for atherosclerotic diseases are needed as they remain the leading killers worldwide. Therapies that target each of the different cell types that influence the formation of atherosclerotic plaque have translated into lifesaving therapies. Characterizing a novel key cell population that plays a pathogenic role in atherosclerosis will open entirely new avenues for therapies. Our preliminary single cell transcriptomic data and histology of human and murine atherosclerotic plaque have identified an understudied population of cells that we define as Adventitial Fibroblasts (AdvFib). Enabled by an innovative genetic tool, our preliminary data has unveiled a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.