NIH R01 · 2025
Harnessing Platelet-Endothelial Interactions for Exosome Delivery
PROJECT SUMMARY Studies have demonstrated that adult stem cells such as mesenchymal stem cells (MSCs) repair myocardial infarction (MI) or ischemia/reperfusion (I/R) injury by indirect paracrine mechanisms rather than by differentiation and tissue replacement. In the past decade, exosomes have emerged as promising cell-free agents for treating ischemic injury. Several exosome-based therapeutic companies have launched early phase clinical trials. Like most therapeutics, there is an urgent need for effective delivery strategy to ensure a sufficient number of exosomes to reach the injured tissue. Since they are nanosized natural lipid bilayer particles, one option is vascular delivery.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.