NIH R01 · 2025
Super-sensitive vibrational imaging by synergic development of instruments and probes
Project summary Although fluorescence microscopy has matured into a prevalent imaging method for biomedical researchers, fluorescence spectroscopy exhibits several fundamental limitations: (1) lack of composition information; (2) inability of imaging small biomolecules; (3) color barrier of multiplexing imaging; (4) lack of chemical sensitivity. To this end, the advent of stimulated Raman scattering (SRS) microscopy have revolutionized chemical imaging. Most importantly, recent developments have proven that SRS microscopy can be complimentary to fluorescence in addressing the above-mentioned limitations: (1) revealing chemical compositions by targeting their endogenous chemical bonds; (2)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.