NIH R01 · 2025
Understanding functions of LTR retrotransposon activation in preimplantation development
Understanding the functions of LTR retrotransposon activation in preimplantation development Abstract Accumulating evidence indicates that retrotransposons, especially long terminal repeats (LTRs), can act as cis- regulatory elements, such as promoters and enhancers, to regulate host gene expression. After fertilization, the mammalian zygote activates its own genome in a process called zygotic gene activation (ZGA). Hundreds of retrotransposon subfamilies—which are repetitive elements that constitute ~40% of our genomes—become activated as well. This wave of retrotransposon activation is considered critical for ZGA and early embryogenesis, with its disruption leading to embryonic arrest.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.