Chen Lab

Research focus

NIH R01 · 2025

Engineering Biologics for treatment of enteric diseases

Abstract Enteric diseases, including both acute and chronic diarrhea and constipation, are among the most common ailments afflicting humans. Many enteric diseases, such C. difficile infection (CDI) and inflammatory bowel disease (IBD), are currently treated with systemically delivered biologics (e.g. bezlotoxumab for CDI and anti- TNF antibodies for IBD). However, since the GI lumen is also home to trillions of microbes that may cause sepsis if present in the blood, the GI tract has evolved over millions of years to strictly prohibit the diffusion of large molecules, such as proteins and peptides, between the GI lumen and the blood circulation. Consequently, the GI lumen is not readily…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.