NIH R01 · 2025
Critical Sorting Steps and Pathways in the Trafficking of Cardiac Sarcoplasmic Reticulum Proteins
Cardiac hypertrophy can lead to heart failure, with few treatment options. Hypertrophic growth inevitably requires mechanisms of protein distribution, as studies show the involvement of both increased mRNA translation and mRNA trafficking along microtubules. Yet, how the distribution of membrane proteins occurs and responds to hypertrophic growth is unknown. While sarcoplasmic reticulum (SR) Ca handling is key to hypertrophy, we do not know how trafficking of SR proteins occurs using cardiomyocyte specific mechanisms, nor its regulation and response to hypertrophy, which precludes discovery of key targets for therapeutics. To probe this mechanism and identify sites of regulation, we have…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.