NIH R01 · 2024
Programming multi-pronged immune response to glioblastoma with IL-13Ra2/TGF-b CAR-T cell therapy.
ABSTRACT Glioblastoma multiforme (GBM) is the most common type of primary brain tumor, with a five-year survival rate of only 5.5%. Chimeric antigen receptor (CAR)-T cell therapy has shown safety but limited efficacy in the treatment of patients with GBM to date. GBM is characterized by dramatic antigen heterogeneity, thus immunotherapy targeting any single antigen is unlikely to achieve complete and durable response. In addition, GBM cells and surrounding tumor stroma overproduce transforming growth factor beta (TGF-β), which not only promotes tumor growth and metastasis, but also actively modulate the immune response by suppressing T-cell function and recruiting suppressive myeloid cells.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.