NIH R01 · 2024
Abstract The overall goal of this proposal is to develop novel biomaterials for intracellular therapeutics delivery. While messenger RNAs (mRNAs) are recognized as promising candidates for RNA therapeutics (such as anti- inflammatory drugs) as well as research tools (such as delivering Cas9 mRNA for gene editing), unlike many chemical molecules or antibody proteins, mRNAs need to be delivered into cell cytoplasm to be functional. Various types of materials have been developed for successful intracellular delivery of small RNAs, but it is still a major challenge to achieve effective delivery of mRNAs at both cellular and systemic levels. We aim to overcome this by optimizing the biointerface…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.