Chen Lab

University of Illinois at Urbana-Champaign

ENGINEERING (ALL TYPES)

Champaign · United States

NIH-funded
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NIH R01 · 2024

Brain Vascular Signatures in Drug-induced Recurrent Hypoglycemia and Associated Cognitive Dysfunction

ABSTRACT Type 2 diabetes mellitus (T2DM) poses a serious global health issue, affecting millions globally, with a concerning rise in younger age groups. T2DM patients often suffer from hypoglycemia, typically medication- induced, leading to severe consequences and cognitive impairment. Frequent hypoglycemic episodes can give rise to 'hypoglycemia unawareness,' escalating the risk of severe hypoglycemia and cognitive decline, including dementia. Investigating cognitive alterations induced by hypoglycemia in T2DM patients is complex due to the interplay of vascular responses, brain activity, and cognitive functions. Current functional imaging techniques can visualize brain vascular parameters…

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