NIH R01 · 2025
Clostridioides difficile Zinc-binding PBPs as anti-sporulation targets
Abstract Clostridioides difficile is the leading cause of nosocomial infection. The use of b-lactam antibiotics, especially cephalosporins, is a major risk factor for infection, but high dietary zinc concentrations have also been shown to increase infection rates. Current treatments of C. difficile infection (CDI) are plagued by high recurrence frequency due to C. difficile spores, which are the main vehicle of transmission and highly resilient against harsh environmental conditions. We hypothesize that penicillin-binding proteins (PBPs), the target of b-lactam antibiotics, may play important roles in C. difficile cephalosporin resistance while serving as valuable targets for novel…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.