NIH R01 · 2024
Exposure to Metal-Mixtures and Coronary Heart Disease Across Diverse Populations
Coronary heart disease (CHD) is the leading cause of mortality and disability worldwide, and accounts for 13% of global deaths and 370,000 deaths annually in the US. Accumulating evidence suggests exposure to inorganic arsenic (As) and other (often co-occurring) toxic metals may be an independent risk factor for CHD. Although most individuals are simultaneously exposed to different metals, most studies focused on the toxicity of individual metals. Combinations of exposures may have different, and possibly stronger, effects than each exposure separately. However, there were no large epidemiologic studies on either the effects of metal mixtures (specific combinations of metals) or metal–metal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.