NIH R01 · 2025
17α-estradiol and sex-differences in HAND with methamphetamine
Project Abstract The pathogenesis of HIV-associated neurocognitive disorders (HAND) in ART era is complex and may result from low levels of HIV-1 replication/HIV-1 proteins, ART drugs, drug of abuse, and the misuse of stimulants such as methamphetamine. It is envisioned that combined exposure of these HIV-related factors leads to reversible synaptodendritic impairment that contribute to the development of HAND. Growing evidence indicates the existence of sex differences in both HAND and in methamphetamine misuse; Women living with HIV have greater neurocognitive impairments, and methamphetamine misuse leads to more severe gray matter damage and cognitive deficits in female. One factor for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.