NIH R01 · 2024
Targeting Gq pathway in uveal melanoma
Project summary: Uveal melanoma (UM) is the most common intraocular cancer in the United States and accounts for about 5% of all kinds of melanomas. Approximate 50% of UM patients develop metastases, predominantly to the liver with 100% mortality. UM lacks mutations in BRAF, NRAS, NF1 and KIT common to other melanoma types. Instead, over 90% harbor somatic activating mutations in the Gaq family members GNAQ or GNA11, with the remainder carrying mutations of genes also acting in the Gaq signaling pathway such as CYSLTR2, a Gaq- coupled GPCR, phospholipases C b4 (PLCb4), a direct effector of Gaq. Therefore, UM is genetically defined by activating mutations of the Gaq pathway. Despite dramatic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.