NIH R01 · 2024
A novel mitochondria-to-lysosome stress signaling pathway in degenerative disease and aging
This application synergizes expertise from two groups, with one specialized in mitochondrial biology and proteostatic signaling and the other in V-ATPase biochemistry and vacuolar/lysosomal biology. Mitochondria are multifunctional organelles. In addition to their major role in ATP production, mitochondria are also involved in other cellular processes including stress signaling and cell death. However, under many pathophysiological conditions and during aging, to what extent impairment to non-bioenergetic mitochondrial functions contributes to the decline of cell fitness is poorly understood. We found that various mitochondrial stressors can directly induce proteostatic stress in the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.