NIH R01 · 2024
The Role of Immature Tumor Subpopulations In Pediatric Rhabdomyosarcoma
PROJECT SUMMARY / ABSTRACT Rhabdomyosarcoma (RMS) is a devastating pediatric soft tissue cancer with morphological features of develop- ing skeletal muscles. Although most patients with RMS achieve a complete remission, one third will develop disease recurrence which is associated with a dismal clinical outcome. These clinical challenges underscore an urgent need to identify patients at risk for resistance and develop better therapy to reduce the risk of recurrence. Our pilot study revealed that rhabdomyosarcoma tumors have developmental intratumoral heterogeneity: differ- ent cells in a single tumor harbor transcriptomic feature of different myogenic stages. Moreover, tumor cells with…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.