Chen Lab

Duke University

OPHTHALMOLOGY

Durham · United States

NIH-funded
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NIH R01 · 2024

Elucidating perifoveal vascular development in infants

PROJECT SUMMARY One out of every ten infants is born preterm. Preterm birth can cause retinopathy of prematurity (ROP), a leading cause of childhood blindness. Even in the absence of ROP or neurological disability, children born preterm exhibit subtle impairments in visual acuity and visual function, though the etiology of this suboptimal vision in preterm infants remains unclear. The fovea, an indentation in the central retina, is the most critical region determining visual acuity. The fovea is surrounded by anastomosis of three layers of capillaries, forming the foveal avascular zone. It is well-established that children and adults with history of prematurity have a small or absent foveal…

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