NIH R01 · 2025
Novel Role of Bscl2 in Cardiac Substrate Metabolism and Function
Project Summary Metabolic perturbations underpin a wide variety of cardiomyopathies. Currently, there are no specific treatments for preventing the onset or progression of cardiomyopathies to heart failure, one of the leading causes of death and disability worldwide. BSCL2/Seipin is a highly conserved endoplasmic reticulum (ER) protein widely implicated in lipid droplet biogenesis and triglyceride (TG) metabolism. However, the molecular machinery responsible for BSCL2-regulated cardiac lipid metabolism has not been elucidated. This grant addresses novel linkages between BSCL2, TG lipolysis, and mitochondrial function in the heart. We found that cardiac BSCL2 deletion elevates adipose…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.