NIH R01 · 2025
Calciprotein Particles and Vascular Calcification in Patients with Chronic Kidney Disease
PROJECT SUMMARY Vascular calcification is common in patients with chronic kidney disease (CKD) and contributes to mortality. Calciprotein particles (CPPs) have emerged as a promising therapeutic target. In CKD, excess CPPs build up in the blood and transform into pathogenic forms—primary and secondary CPPs, which have been shown in preclinical studies to cause vascular calcification by inducing inflammation, dysfunction of endothelial cells, and calcification of vascular smooth muscle cells. Whether and how serum CPPs lead to vascular calcification in CKD patients is an important knowledge gap. Our study will help fill this gap by testing the hypothesis that serum CPPs from CKD patients…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.