NIH R01 · 2025
DSPP signaling in dentinogenesis
Project summary One of the most important goals of dentistry and the NIDCR/NIH is to generate a whole “Bio- Tooth”. Dentin is a critical structural component of tooth. Although it has made great progress of dentin development benefit for numerous hereditary syndromes and chromosomal anomalies, many gaps have been remained. Understanding signaling pathways of dental mesenchymal lineages and dentin formation would provide an avenue for repair and regeneration of dentin. Dentin sialophosphoprotein (Dspp) is highly expressed in odontoblasts and dentin and processed in to dentin sialoprotein (Dsp) and dentin phosphoprotein (Dpp). Dsp and Dpp mutations are associated with dentinogenesis…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.