NIH R01 · 2024
Functional Interrogation of Type 2 Diabetes-associated Genetic Network
Abstract. Type 2 diabetes (T2D) is a polygenetic disease marked by impaired insulin secretion in pancreatic islet cells. Although genome-wide association studies (GWAS) have identified many T2D-associated genetic variants/genes, understanding the molecular mechanism and cellular consequence of GWAS identified hits remains challenging. In addition, little is known about the interaction network of GWAS identified T2D genes/variants. Recent advances in human pluripotent stem cells (hPSCs) and CRISPR-based technologies have enabled in vitro model systems for exploring the impact of T2D-associated genes and genetic network on islet dysfunction. In our recent study, we generated a panel of…
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