NIH R01 · 2024
Novel Mechanisms underlying abdominal aortic aneurysm progression
Summary/Abstract Abdominal aortic aneurysm (AAA) is a potentially lethal disease that lacks pharmacological treatment. Although vascular inflammation is the initial event leading to AAA formation, aorta rupture due to artery wall weakening is responsible for the high mortality rate in this silent killer. Aortic wall weakening in AAA is primarily caused by aorta media degeneration, elastin breakage and impaired adventitia response. The media degeneration is driven by programmed cell death (e.g., apoptosis and necroptosis) of medial smooth muscle cells (SMC). However, there are critical knowledge gaps concerning mechanism(s) or key factor(s) governing SMC survival in aortic wall. Moreover,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.