NIH R01 · 2024
Project Summary Current NIAAA strategic plan calls for efforts to identify novel molecular actions of alcohol and new remedies to mitigate alcohol-impacted brain regions. Ever-changing research tools have exponentially accelerated our understanding of brain regions and circuits affected by alcohol use and comorbid affective disorders. However, efforts towards the understanding of molecular mechanisms for altered neural activity in these impacted regions have lagged behind. To fill in this gap, we will explore a previously unknown molecular mechanism whereby ethanol modulation of brain cholesterol in the prefrontal cortex (PFC) leads to aberrant mGluR2 function and glutamate transmission in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.