Chen Lab

Columbia University Health Sciences

BIOSTATISTICS & OTHER MATH SCI

New York · United States

NIH-funded
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NIH R01 · 2025

Improving the analysis and use of contaminated immunoassays: from methods development to implementation

PROJECT SUMMARY Immunoassays – tests that estimate the concentration of analytes in a sample using antibody-antigen binding reactions – are widely used for clinical diagnostics, biopharmaceutical analysis, and environmental monitoring. The current method for estimating concentrations of analytes measured in immunoassays has several limitations, including large measurement errors, difficulty in estimating very low or high concentrations, and noisy estimation. In addition, with the advance of new technologies using multiplex assays, multiple analytes can be measured simultaneously in a single plate, but the current method fails to account for the potential correlations between multiple…

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