NIH R01 · 2025
Interrogating Type I Interferon signaling in breast cancer brain metastasis
PROJECT SUMMARY The brain is one of the common organs for breast cancer recurrence. Breast cancer brain metastasis is increasingly becoming a significant clinical problem due to its rising incidence and limited efficacy of existing systemic therapies. Metastasis is the consequence of favorable interactions between the invaded cancer cells and the microenvironment in the distal organ. To cancer cells, the brain has the most unique microenvironment since the stromal cells in the brain do not exist in any other organs. This explains why therapeutic strategies, which efficiently diminish primary and non-brain metastatic breast tumors, are ineffective in controlling the established brain…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.