NIH R01 · 2025
Cell Senescence Regulating Osteoarthritis Progression: Sex-dependent Mechanisms
Osteoarthritis (OA), a leading cause of disability in the elderly (aging OA), is a complex degenerative joint disease involving articular cartilage degradation, chronic inflammation, and bone remodeling. In addition, joint injury can trigger post-traumatic osteoarthritis (PTOA). The prevalence and severity of knee OA are higher in women than men during aging, although female mice are more resistant to OA progression after injury. The scientific challenge is the incomplete understanding of the sex-specific mechanisms regulating OA progression, which hampers the development of disease-modifying osteoarthritis drugs that can target the process. The scientific goal of this project is to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.