Chen Lab

Research focus

NIH R01 · 2024

Decoding the signature of sperm RNA & RNA modification of environmental stressors on the intergenerational transmission of metabolic phenotypes

Project Summary Emerging evidence has shown that small non-coding RNAs (sRNAs) harbor a diversity of RNA modifications. RNA modifications have the potential to store a secondary layer of labile biological information that is responsive to various environmental exposures and can modulate RNA properties such as stability and interaction potential, thus contributing to complex physiological/pathological processes. In our previous mouse model of paternal high- fat diet (HFD)-induced intergenerational inheritance, we found that tRNA-derived small RNAs (tsRNAs) and RNA methylatranserase (Dnmt2)-mediated site-specific RNA modification established a “sperm RNA code” that is required for…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.