NIH R01 · 2024
SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular Arrhythmogenesis
Project Summary The broad and long-term goal of this research project is to test the hypothesis that (1) the response of apamin- sensitive small conductance Ca2+-activated K+ (SK) current (IKAS) to sympathetic stimulation plays an important role in the mechanisms of sex differences in cardiac arrhythmogenesis and that (2) beta-3 adrenoceptor (AR) activation is antiarrhythmic and eliminates the sex difference of IKAS activation during sympathetic stimulation. In the current funding period, we discovered a significant sex difference of both the SK protein and IKAS at baseline and that the magnitudes of sex differences are amplified during isoproterenol or acetylcholine infusion. Apamin…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.