NIH R01 · 2024
Mechanism and therapeutic potential of microglia regulation in glioblastoma
Project Summary Glioblastoma (GBM) is the most lethal form of brain cancer in adults. The median survival of GBM patients is only about 14-16 months after initial diagnosis. Genomic profiling has stratified GBM into various subgroups, which are driven by specific genetic alternations of core signaling pathways. However, targeted therapies, such as therapies against receptor tyrosine kinase signaling, have failed in the clinic. Tumor-cell genetic heterogeneity is one of the main reasons for this failure. In contrast, the tumor microenvironment (TME) of GBM is genetically stable, and are considering as the promising therapeutic targets. Tumor-associated microglia and macrophages (TAMs) are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.