NIH R01 · 2025
Comprehensive analysis of macromolecule structural variability in CryoEM/CryoET
Project Summary This proposal aims to develop computational tools that analyze the structural variability of the macromolecules imaged by Cryogenic electron microscopy (CryoEM) and Cryogenic electron tomography (CryoET). As the function of most macromolecules involves dynamic interactions among their own components or with other molecules, the structural flexibility of those macromolecules is often key to accomplishing their functions. CryoEM/CryoET makes snapshots of macromolecules embedded in vitrified ice, which provides direct information of individual protein particles in different compositional and conformational states. Using advanced computational methods, we will be able to resolve…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.