NIH R01 · 2025
Genetic and biochemical dissection of anterograde signaling for controlling plastid transcription
Abstract The control of organellar gene expression is critical for the cellular programming of all eukaryotic organisms. While perturbing mitochondrial gene expression leads to human pathologies, including cancer, altering plastid gene expression can kill plants. However, the cell signaling mechanisms that control organellar gene expression remain poorly understood. The long-term goal of the PI’s laboratory is to utilize the light-induced plastid differentiation into photosynthetically active chloroplasts in Arabidopsis as a genetic model to interrogate cell signaling mechanisms for controlling organellar gene expression. The current data support the central hypothesis that the red and…
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