NIH R01 · 2025
Functional Diversity of Reactive Astrocytes in Spinal Cord Repair
PROJECT SUMMARY / ABSTRACT As key modifiers of injury outcome following CNS insults, reactive astrocytes represent a rational cellular target for neural repair. CNS injury results in scar-forming astrogliosis at the primary lesion and diffuse astrogliosis in areas of distal axon degeneration, the latter of which is poorly characterized. Without a complete understanding of how reactive astrocyte subtypes impact the CNS injury response, harnessing the full therapeutic potentials of reactive astrocytes will remain unlikely. The long-term goal is to translate knowledge of the diverse functions of reactive astrocytes to treat CNS trauma. Towards this goal, the objective of this proposal is to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.