NIH R01 · 2025
Neuronal microtubule regulation and aging
PROJECT SUMMARY (Neuronal microtubule regulation and its autonomous and non-autonomous effects on aging) Aging is the greatest risk factor for developing neurodegenerative diseases including Alzheimer's Disease (AD). Neuronal aging, defined as a progressive loss of function and structure, predisposes neurons to degeneration. The importance of microtubule (MT) regulation in neurons is underscored by the critical role of MT-associated proteins, e.g. tau and tau-like proteins, whose dysfunction leads to neurodegeneration. Surprisingly, little is known about the role of MTs in the normal aging process. MT regulation is involved on several levels of neuronal function and maintenance of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.