NIH R01 · 2024
Integrative multivariate association and genomic analyses
ABSTRACT Recently, as part of the enhancing Genotype Tissue-Expression (eGTEx) project, methylome data on subsets of GTEx samples (N=987) from nine tissue types of 424 subjects have been generated by co-I Pierce’s lab to complement existing expression quantitative trait locus (eQTL) data. As part of eGTEx, our group conducted the standard methylation QTL (mQTL) mapping for each of the nine tissues and multi-tissue mQTL analysis using existing methods. The challenges in our mQTL analyses motivates the development of the methods in our first aim. In Aim 1, we propose to develop methods for integrative QTL mapping, integrating multi-tissue mQTL with multi-tissue eQTL statistics to improve the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.