NIH R01 · 2024
Enabling translation of cancer cell proliferation PET imaging via droplet radiochemistry technology
PROJECT SUMMARY Despite the widespread use and success of [18F]FDG-PET imaging in oncology, there are many situations where [18F]FDG cannot be used for diagnosis or treatment monitoring, especially for cancers where there is high background uptake, low tissue density, or slow-growing tumors. Infection or inflammation frequently leads to false positives. Many tracers are being developed that provide improved contrast, sensitivity, and accuracy compared to [18F]FDG. Of particular interest is the nucleoside analog [18F]FMAU, which is incorporated into DNA when tumor cells divide, thus directly measuring increased cell proliferation, a universal hallmark of cancer. Promising clinical data of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.