NIH R01 · 2025
Adipokines as novel therapy to promote functional recovery after experimental traumatic brain injury
Traumatic brain injury (TBI) can elicit cognitive disabilities due to mechanical shearing of the vascular supply, damage of the neurovascular unit, and secondary cascades of endothelial and microglial inflammation, and neurodegeneration. TBI increases the risk of clinical dementia, including Vascular Cognitive Impairment and Dementia (VCID), by 1.6 to 3.7-fold, as it directly damages blood vessels and reduces cerebral blood flow. The severity of neurovascular injury after TBI is correlated with the increased risk of developing VCID, with more severe injuries bearing a greater impact on brain vasculature. There is thus an urgent, unmet need for drugs that protect neurons and mitigate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.