NIH R01 · 2025
Biogenesis of mRNA-derived telomerase long noncoding RNA
Project Summary Most RNA molecules transcribed in mammalian cells do not encode for protein sequences. Among these noncoding RNAs (ncRNA) is a vast family of long noncoding RNAs (lncRNAs) that are larger than 200 nt. LncRNAs can modulate cellular protein expression patterns by influencing the transcription of many genes, the post-transcriptional fate of mRNAs and ncRNAs, and the turnover and localization of proteins. Telomerase RNA is a unique class of lncRNA that functions as an integral component of the telomerase ribonucleoprotein complex which maintains genomic stability and cellular immortality in cancer and stem cells. The overarching goal of this project is to understand the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.