NIH R01 · 2024
Phosphoinositide signaling in autophagy
PROJECT SUMMARY Phosphoinositides (PIPs) are minor components of the eukaryotic membrane but major regulators of cellular functions. The seven PIPs are critically involved in nearly every aspect of cell physiology. One of the cellular processes regulated by PIPs is autophagy, a process essential for a broad range of cellular functions and tissue development, and dysregulated in many human diseases. Found on late endosomes and lysosomes, PI(3,5)P2 is necessary for autophagosome maturation, and dysregulation of PI(3,5)P2 biogenesis has been linked to several neurological disorders through defective autophagy. However, the mechanism by which PI(3,5)P2 regulates autophagy is poorly understood.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.