NIH R01 · 2025
Instructive roles of mesenchymal proteoglycans in hair follicle morphogenesis and maintenance
PROJECT SUMMARY Hair is produced in the hair follicles. Hair follicle formation, cycling, and neogenesis relies on extensive cross- talk between hair follicle keratinocytes and dermal papilla cells. This cross-talk is primarily mediated by molecular signaling pathways. In classic models of molecular signaling, a ligand binds and activates a receptor on the surface of a cell to produce a signal into the cell body. Such signal may influence a cell’s ability to proliferate, differentiate, migrate, contract, and more. Integrins exist on the surface of many cell types. They serve three basic functions: adhesion, scaffolding, and signaling. The functions of integrins in the hair follicles are not…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.