NIH R01 · 2024
MSC implantation as a treatment for developmental brain defects in craniosynostosis
PROJECT SUMMARY/ABSTRACT Craniosynostosis is a craniofacial disorder, which is characterized by the premature fusion of cranial sutures with the loss of mesenchymal stromal/stem cells (MSCs). Some craniosynostosis have neurocognitive deficits, which are attributed to abnormally increased intracranial pression (ICP). However, the causes of ICP elevation and brain defects in craniosynostosis are poorly understood. The goal of this proposal is to establish novel mechanisms and a therapeutic strategy by which suture MSC implantation can lead to long-term reduction of ICP and reverse neurological deficits in craniosynostosis. The scientific premise is based on our recently published data (Cell,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.